Scientific Editorial & Integrity Review
The reviewers identified on this page provide independent scientific accuracy review of the Company's published claims and citations. They do not provide medical advice, render diagnoses, prescribe treatments, or otherwise provide medical services to readers or customers. Their review is editorial in nature and is limited to assessing whether the Company's published claims accurately reflect the underlying scientific literature.
Of The Ancients formulations are purpose-built for transparency, meaningful results, and better living. Our mission is to develop evidence-based natural formulations grounded in both traditional wisdom and modern clinical science.
To ensure accuracy and transparency, our product pages, clinical studies, and ingredient science are reviewed by medical professionals with verifiable credentials and research backgrounds. We apply a multiple-review standard across MD, PhD and RN practitioners.
Lead Scientific Reviewer
Robert Woodward, MD
Physician — Psychiatry, General & Geriatric Medicine
42 years in clinical practice
Review completed: August 2026
Credentials & Background
Bachelor of Science in Engineering — Columbia University, New York
Neurophysiology Laboratory, School of Medicine — University of Texas Health Science Center, San Antonio
Doctor of Medicine (MD) — University of Texas Medical Branch at Galveston
Seven years of residency training across General Surgery, Anesthesiology, Emergency Medicine, and Psychiatry
Current practice: Psychiatry, General and Geriatric Medicine, Home Health Medicine and Telemedicine
Review scope: Logic Lion’s Mane formulation and Supplement Facts, Certificate of Analysis, the referenced acute human trial, and on-site clinical claims.
Expert review statement — verbatim excerpts from Dr. Woodward’s recorded scientific review, August 2026:
“Lion’s mane is quite an intriguing mushroom. It is not an hallucinogenic mushroom, but it does contain compounds that act in the brain. The active compounds in lion’s mane work on the hippocampus and the locus coeruleus, centers in the brain and brainstem, responsible for memory formation, working memory, attention and arousal.”
“Research suggests benefits of lion’s mane in cognition, memory, reaction time and happiness with acute, that is, one dose use.”
“This study involved 40 participants, 22 men and 18 women, who were healthy, had no major medical problems or psychiatric illness, and who were not heavy coffee drinkers. All 40 completed the study, a rarity in studies set up like this. The purity and potency of the lion’s mane was verified by an independent laboratory.”
“The results for lion’s mane showed that reaction times were quicker, there were improvements in cognitive tests, improved working memory, and complex attention, and that those subjects who took lion’s mane were happier.”
“The results also raised questions considering exactly how lion’s mane works in the brain to cause these benefits and the need for future studies using advanced physical tests such as EEG and functional MRI.”
“Lion’s mane extract shows promise for improving people’s cognition and memory as well as their working memory and improving happiness. It is not for people who are allergic to mushrooms, or for those expecting miracles.”
— Robert Woodward, MD
Disclosure: Dr. Woodward is a compensated scientific advisor to Of The Ancients and appears in brand educational material. His compensation is not contingent on his findings or on product sales.
Independent Review Panel
The following reviewers independently assessed the Logic Lion’s Mane formulation, the referenced acute trial, and our published claims. Each reviewed the Supplement Facts panel and directions for use.
Ryan Hakim, MD
Neurocognitive Disorders Post-Doctoral Research Fellow · Review completed 20 November 2025
Doctor of Medicine (MD), Loyola University Chicago – Stritch School of Medicine (2020–2024) · Post-Doctoral Neurocognitive Research Fellow, University of Texas Health Science Center at Houston (2025–present) · Incoming Neurology Resident Physician, University of Arizona · Neuro-Imaging Clinical Research Scholar, Epilepsy Monitoring Unit, UC San Diego Health (2024–2025)
“After reviewing Logic Lion’s Mane and its referenced randomized, double-blind, placebo-controlled crossover trial (La Monica et al., Nutrients 2023), I found that the product’s core claims—acute support for attention, working memory, and reaction time in healthy adults—are consistent with the study’s findings following a ~1 g dose of standardized Lion’s Mane extract assessed 60–120 minutes after ingestion. Notably, the crossover design—where each participant serves as their own control—adds methodological rigor and strengthens confidence in the reliability of the acute effects reported. Logic’s liquid formulation provides a comparable daily amount (970 mg) of the same clinically studied ingredient and presents these nootropic benefits without making disease-treatment claims, while clearly disclosing study sponsorship and formulation differences. Overall, the website’s scientific positioning is evidence-aligned and transparent, with the important caveat that current data support short-term cognitive effects in healthy adults rather than long-term outcomes or use in clinical populations.”
— Ryan Hakim, MD
Mark Matus, MD
Neuroscience & Neurovascular Research · Review completed October 2025
Doctor of Medicine (MD), University of Debrecen (2013–2020) · Research Fellow, Neuroanesthesia & Neuroscience, Mayo Clinic (2020–2022) · PhD Researcher, Cerebrovascular Imaging & Neurovascular Physiology, Semmelweis University (2022–present) · Founder & Medical Director, Matus Medical
“I reviewed Logic Lion’s Mane and its referenced clinical study (La Monica et al., Nutrients 2023). The study, a randomized double-blind, placebo-controlled crossover in 40 healthy adults, showed acute cognitive improvements (attention, working memory, reaction time) at 60–120 minutes following 1 g of standardized Lion’s Mane extract. Logic provides 970 mg/day of the same standardized ingredient in liquid form; this minor difference and the study’s sponsor funding are transparently disclosed.”
— Mark Matus, MD
External profile: matusmedical.com/about
Carolina A. Figueroa, MS Nutrition, PhD
Clinical Nutrition Science · Review completed November 2025
PhD, Biomedical/Medical Engineering, University of Maine (2015–2020) · Research Fellow, Harvard Medical School (2023–2024) · Postgraduate Course in Clinical Pharmacology, Drug Development & Regulation, Tufts University (2025)
“Logic Lion’s Mane and its supporting randomized clinical trial (La Monica et al., Nutrients, 2023) provide evidence that a single 1 g dose of Nordic Lion’s Mane improved working memory, attention, and reaction time after 2 hours, and enhanced subjective happiness and life satisfaction starting at 1 hour.”
— Carolina A. Figueroa, MS Nutrition, PhD
External profile: linkedin.com/in/carolinaafigueroa
Miranda Adams, RN, BSN, CGRN
Registered Nurse · Review completed 29 September 2025
Registered Nurse, Mayo Clinic · Bachelor of Science in Nursing · Certified Gastroenterology Registered Nurse (CGRN) · Clinical experience in hospital-based internal medicine and interdisciplinary care
“The advertised product Logic Lion’s Mane by the brand Of The Ancients has been determined to be clinically accurate. Overall, the correlation between the product’s claims and the study’s findings is strong. The clinical evidence supports the advertised benefits, particularly the acute cognitive improvements observed at the two-hour mark. However, further peer review and additional research could reinforce the generalizability of these results to wider populations.”
— Miranda Adams, RN, BSN, CGRN
External profile: linkedin.com/in/miranda-adams-rn-bsn-cgrn
The Referenced Clinical Trials
MycoThrive™ Lion’s Mane, the standardized extract in Logic™, has been evaluated in two human clinical trials.
Study One — acute, single dose
La Monica MB, Raub B, Ziegenfuss EJ, Hartshorn S, Grdic J, Gustat A, Sandrock J, Ziegenfuss TN. Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion’s Mane Extracts on Cognitive Performance. Nutrients, 6 December 2023;15(24):5018. DOI: 10.3390/nu15245018
Randomized, double-blind, placebo-controlled crossover design in 40 healthy adults. Funded in part by Applied Food Sciences, the supplier of MycoThrive™.
Study Two — 45 days of daily use
Center for Applied Health Sciences. 45-day randomized, double-blind, placebo-controlled parallel-arm trial in 87 healthy adults aged 40–65, published in the Journal of Translational Science. Three arms: 1 g per day MycoThrive™ Lion’s Mane fruiting body extract, 1 g per day of a commercial mycelium-and-fruiting-body blend, or a maltodextrin placebo.
This study has not yet been assessed by the reviewers listed above. All review statements on this page were completed before it became available to us, and each refers to the acute trial. It will be included in the next scheduled review.
Full citation details, findings, and study limitations for both trials — including the distinction between within-group and between-group results — are set out on our References & Clinical Evidence page.
Editorial Independence & Compensation
Reviewers assess scientific accuracy only. Their role is to verify that clinical statements align with the underlying evidence, and that disclosures and disclaimers are properly presented.
No reviewer’s compensation is contingent on their findings, on the conclusions they reach, or on product sales. Dr. Woodward serves as a compensated scientific advisor and appears in brand educational material; that relationship is disclosed wherever his statements appear.
Reviewers do not diagnose, treat, or advise individual readers. Nothing on this page is medical advice. Talk with your own physician before beginning any supplement, particularly if you are pregnant or nursing, have a medical condition, or take prescription medication.
Review Timeline
| Reviewer | Credentials | Date | Scope |
|---|---|---|---|
| Robert Woodward, MD | Psychiatry, General & Geriatric Medicine — 42 years | Aug 2026 | Formulation, Supplement Facts, CoA, acute trial and on-site claims |
| Ryan Hakim, MD | Neurocognitive Research | Nov 2025 | Clinical claims & product review |
| Carolina A. Figueroa, MS, PhD | Nutrition / Metabolism | Nov 2025 | Clinical claims & nutrition science |
| Mark Matus, MD | Neuroscience / Clinical Medicine | Oct 2025 | Clinical claims & product review |
| Miranda Adams, RN, BSN, CGRN | Mayo Clinic RN | Sep 2025 | Medical accuracy across site content |
Next review scheduled: on receipt of the full 45-day trial publication.
Questions About Our Clinical Review Process?
Contact our Science & Quality team: hello@oftheancients.com